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KMID : 0882420130840040531
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Korean Journal of Medicine
2013 Volume.84 No. 4 p.531 ~ p.540
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Effect of Intravenous High-Dose Selenium Supplementation in Patients with Systemic Inflammatory Response Syndrome: A Pilot Study
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Kim Mi-Jeoung
Lee Ki-Jong
Oh In-Myung
Oh Dong-Hyun
Yoo Kyoung-Hwa
Park Ju-Sang
Jang Eun-Jeong
Park Sang-Jong
Park Sang-Woon
Kim Sang-Jung
Baik Hyun-Wook
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Abstract
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Background/Aims: Systemic inflammatory response syndrome (SIRS) can induce occurrence of oxidative stress. Several reports have evaluated selenium supplementation in SIRS patients with encouraging results. Therefore, we evaluated the effect of intravenous high-dose selenium supplementation in patients with SIRS. Methods: Patients were randomly assigned to one of two groups: the selenium group (800 μg/day of selenoic acid by intravenous bolus injection for 7 days) or the placebo group. Physical and biochemical measurements were used to assay acute phase reactants, severity of illness index and serum selenium concentration. Results: A total of 23 patients classified as mild-to-moderate severity of illness index were enrolled between March 2010 and October 2011. Serum selenium concentration increased in the selenium group after intervention, but there was no significant change in the placebo group. In the selenium group, the white blood cell (WBC) count, serum level of c-reactive protein (CRP), Acute Physiology and Chronic Health Evaluation II (APACHEII) score and Sequential Organ Failure Assessment (SOFA) score improved significantly by days 7 and 14 compared with day 0. In the placebo group, only the serum CRP level at day 14 and APACHE II score at days 7 and 14 improved significantly compared to day 0. Conclusions: Intravenous supplementation with high-dose selenium improved acute phase reactants and the severity of illness index in patients with SIRS. However, larger prospective clinical trials are required to determine the efficacy of selenium supplementation in SIRS patients.
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KEYWORD
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Selenium, Systemic inflammatory response syndrome, Prognosis, APACHE II
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